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It is introduced into the market in carton boxes containing five 10 ml colourless ampoules- in 50 ml and 100 ml honey-coloured flacons. |
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ASCORVET Solution for Injection is a very light yellow coloured, odourless, clear solution and contains 250 mg ascorbic acid (Vitamin C) per ml. |
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ASCORVET Solution for Injection is a light yellow coloured clear solution. Ascorbic acid known as Vitamin C is one of the micro nutrients that is absolutely essential for the maintenance of healthy life and for growth, development and optimum productivity in developed living beings. Concerning its physiological effects in the bodies of living beings, it acts as a hydrogen carrier in multi-directional oxidation and reduction reactions primarily in oxidations. A significant portion of the reactions it is directly involved in is closely associated with the construction and maintenance of the integrity of tissues of mesenchymal origin in animals. Thus, the synthesis of bone and teeth matrix, and collagen, proteoglycans and other organic participant substances participating in the formation of connective tissues among capillary endothelial cells is accomplished. The indicated physiological and pharmacological effects constitute the basis for its protective and therapeutic effects towards the disease of scurvy (scorbutus). Ascorbic acid has a definitive significance in the synthesis and secretion of hormones prepared in the adrenal cortex and gonadal glands. With such effects, it increases the domestic animals’ resistance to negative factors that cause stress, supports and stimulates the immune system and strengthens their reproductive performance. It supports the in vivo effects of vitamins A and E, is involved in in vivo synergistic interaction with them and allows for the preservation of the physiological values of the same vitamins. Parallel to the indicated properties, it enhances the efficacy of amidifying enzymes involved in numerous metabolic events and synthesis reactions, and helps with the hydroxyllation of dopamine and noradrenaline. At the same time, it increases blood production by stimulating the haematopoietic system. Ascorbic acid acts as a mediator in the synthesis of hydroxymethyl lysine from proteins and in its conversion to carnitine. Thus, it facilitates the transfer of energy needed in cases of excessive effort and stress. In the drug metabolism carried out by the microsomal enzymes in the liver, it undertakes important duties in the conversion of folic acid to folinic acid and in tyrosine metabolism. There is plenty of scientific evidence indicating that ascorbic acid reduces the toxicity of the diphteria toxin by binding to it and that it has a protective role against anaphylactic shock and toxications especially in infections that cause damage in the adrenal glands, stomach and the intestines. Ascorbic acid administered via the parenteral route in domestic animals, is rapidly absorbed and distributed in the whole body on a large scale including the intracellular structures. Its concentration in leucocytes and thrombocytes is higher than its concentration in the plasma and erythrocytes. It is found at a high ratio in the glandular structures in the body and at a low ratio in muscular and fat tissues. It is stored at a limited scale in the body. In all mammals primarily in rats (excluding humans) starting from glucose ascorbic acid is synthesised over d-glycuronic acid and l-glycuronic acid. Ascorbic acid is disintegrated down to carbon dioxide in the animal body primarily in the liver and also in some other tissues. Ascorbic acid and its metabolites taken from the outside and endogenously synthesised is primarily excreted from the body through urine. |
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